This paper discusses the mechanism of “resource curse” and presents suggestions against the occurrence and further expansion of “curse” effect. The natural resources dependence means the direct impact on economy by decreasing resources and indirect impact by squeezing effect. This paper, based on 31 Chinese provinces'panel data in 1999—2015, studies their correlation and conducting mechanism among natural resources dependence, technical advances and economic growth with results showing an upside down U shape between natural resources dependence and economic growth, a U shape between technical advances and economic growth. The natural resources dependence impacts technical advances, and indirectly impedes economic growth through technical advances. Proposals are presented to avoid or mitigate “resources curse” on controlling mining and use of natural resources in resource-abundant area, transforming and upgrading industries, getting rid of resource dependence, increasing research input and improving innovation efficiency.